Zayd Khaliq - Local receptor control of axonal excitability and striatal dopamine release
290 Jane Stanford Way, Stanford, CA 94305
Gunn Rotunda (E241)
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Local receptor control of axonal excitability and striatal dopamine release
Abstract
Axons of dopaminergic neurons transmit reinforcement signals to the striatum through patterns of propagating action potentials. Within the striatum, dopamine signals are shaped independently by input arriving from the local striatal circuit as well as by receptor-mediated conductances that directly influence axonal excitability and dopamine release. This lecture will discuss the mechanisms by which local receptors shape the subthreshold membrane potential of dopaminergic axons, propagated firing, and ultimately striatal dopamine release.
Zayd Khaliq
NINDS
Dr. Zayd Khaliq is a Senior Investigator at the National Institute of Neurological Disorder and Stroke Intramural Research Program (NINDS IRP) where he heads the Cellular Neurophysiology Section. He is also jointly appointed to National Institute on Drug Abuse Intramural Research Program (NIDA IRP). The work in his laboratory focuses on the cellular neurophysiology and synaptic control of neurons in the midbrain dopamine system. He is interested in the diversity of dopamine neuron subpopulations as defined by their excitability, participation in identified circuits as well as their expression of biochemical markers. His work also examines how excitatory, inhibitory, and modulatory receptors contribute to signal processing within subcellular compartments such as dendrites, and axons and ultimately how this process contributes to firing and release during dopamine-dependent behaviors.
Hosted by - Richard Roth (Jun Ding lab)
About the Wu Tsai Neuro Seminar Series
The Wu Tsai Neurosciences Institute seminar series brings together the Stanford neuroscience community to discuss cutting-edge, cross-disciplinary brain research, from biochemistry to behavior and beyond.
Topics include new discoveries in fundamental neurobiology; advances in human and translational neuroscience; insights from computational and theoretical neuroscience; and the development of novel research technologies and neuro-engineering breakthroughs.
Unless otherwise noted, seminars are held Thursdays at 12:00 noon PT.